In the aftermath of the destruction of the desert planet Arrakis, also known as Dune, a new power struggle unfolds. The remnants of the Old Empire have succumbed to the dominance of the Honored Matres, a fierce matriarchal cult. However, a formidable faction, the Bene Gesserit, emerges as the last potential resistance to the complete conquest by the Honored Matres.

Led by Mother Superior Darwi Odrade, the Bene Gesserit have established their presence on a green world located on the planet Chapterhouse. Paradoxically, they are transforming this lush environment into a desert, strategically inching towards dominance. Their ambitious plan involves mastering the breeding of sandworms, the colossal creatures that produce the highly coveted spice melange.

The spice, a commodity of unparalleled value, holds the key to controlling the galaxy. As the Bene Gesserit inch closer to their goal, they wield a powerful weapon—a man who has experienced countless lifetimes. This enigmatic figure once served under the God Emperor Paul Muad'Dib, and his presence adds an intriguing layer to the unfolding saga. In "Chapterhouse: Dune" by Frank Herbert, the epic tale continues, weaving together politics, power, and the mysterious force that shapes the destiny of the universe.